Wednesday, July 11, 2007

A Little FYI for Your PMS Migraine

Naratriptan Tolerable Long-Term for Menstrual Migraine Prophylaxis

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NEW YORK (Reuters Health) Jul 05 - Naratriptan twice daily is well tolerated when taken for 6 continuous days per month for up to 1 year for the prevention of menstruation-related migraine, results of a study indicate.
"For many of the approximately 18% of US women with migraine, menstruation is a predictable trigger of migraine attacks," note Dr. Jan Lewis Brandes, from Vanderbilt University School of Medicine in Nashville, and colleagues in the June issue of Headache.
While naratriptan is not approved for migraine prophylaxis, it has been shown to be significantly more effective than placebo for short-term prevention of menstrual migraine, they point out.
Dr. Brandes' group studied the tolerability of naratriptan 1 mg twice daily starting 3 days before the expected onset of menstrually related migraine and continuing for a total of 6 days. Women in the study had the option to use an additional 2.5-mg dose for breakthrough migraines.
A total of 457 women took at least one dose of naratriptan on study; 318 and 131 completed 6 and 12 months of treatment, respectively.
According to the investigators, the only adverse event occurring at an incidence of more than 2% during the 6-day treatment periods when 1-mg BID naratriptan was taken was ear, nose, and throat infection (3%) -- even when an additional 2.5-mg dose was taken.
There were no serious drug-related adverse events recorded and no patients experienced clinically relevant drug-related changes in electrocardiograms, vital signs, or clinical laboratory tests.
Furthermore, women reported that they did not have a migraine in roughly 50% of perimenstrual periods during which naratriptan prophylaxis was used. The efficacy of naratriptan for menstrual migraine prophylaxis did not wane over time in the 131 patients who remained in the study for the full 12 months.
"Results suggested that naratriptan reduced headache impact when used for up to 12 months for the short-term prevention of menstrually related migraine," Dr. Brandes and colleagues also report.


Migraineur said...

"Dr. Brandes' group studied the tolerability of naratriptan 1 mg twice daily starting 3 days before the expected onset of menstrually related migraine and continuing for a total of 6 days."

Now if they would just come up with a migraine prophylactic for those of us with irregular periods. Thanks to early onset perimenopause, I couldn't tell you when I expect my next period, much less when I expect my next menstrual migraine!

I know, I know, we're never satisfied, are we?

Anonymous said...

I saw this video about migrains and income being linked. ( ) is this true? how can it be true? - Kate from The health Desk at

deborah said...

uh, no never. perhaps it has somethng to do with them there ovaries. Oh yeah, and that screaming migraine that seems to come on for no apparent reason. go figure!!

deborah said...

As far as the video at The News Room; I have watched, and I've read the report. If you'll note the information out there, thoroughly,and all of it, you'll understand it better. Only 6% of teens report migraines as of the video report.

Perhaps as reported, due to associated stress, diet and nutrition and limited access to medical care; they are less likely to not only seek accurate treatment, but unable to spot triggers of their migraines.

Harmonica Man said...

My PMS migraine comes from a different source ;-)

(please don't tell my wife I said that)

deborah said...

Thanks, Jeff - I about fell off my chair laughing. I needed that. funny

Migraine Chick said...

I'm plagued by early onset perimenopause, too. I never know when my period is going to start next, or my pms, or my migraines. How on earth would I ever figure out three days before?

Joanna said...

totally off-topic, but since you had left me that great msg, and in case you didn't see my reply after it:
;-) Good eyes, Deborah! That indeed was shortly after Boyd’s solo album was released (’03-ish, I know it was before my headache craziness began!) at a Borders store. He didn’t perform or anything, but he talked a lot about music preservation in schools and the cd and whatnot. Very cool guy!! I was definitely all jumpy inside but kept it as cool as I could - I am also a HUGE DMB fan. He was so nice and was basically all smiles the whole time. I just have to work on meeting the rest of the guys now ;-)

deborah said...

I am very impressed! I would never have stayed that cool and collected.

hey, I did meet the Clash when I was working at Friendly's as a teen. Road Crew and all.